Search Results

Randomised, Open-Label, Phase III Study of Saruparib (AZD5305) Plus Camizestrant versus Physician’s Choice CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant for the First-Line Treatment of BRCA1, BRCA2, or PALB2 Mutations and Hormone Receptor-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH non-amplified) Advanced Breast Cancer (EvoPAR-Breast01)(D9722C00001) MOA: Saruparib (AZD5305) is a selective inhibitor of PARP1, with…

Phase 2, randomized, multicenter, open-label neoadjuvant study evaluating zanidatamab in combination with chemotherapy in participants with HER2-positive breast cancer (EmpowHER 208) MOA: Zanidatamab is a HER2-targeted bispecific antibody against ECD2 and ECD4 domains of HER2 Key Eligibility: Stage II or III, tumor ≥2 cm, histologically confirmed BC Inflammatory BC (T4d) are eligible Bilateral BC excluded…

Open-Label, Phase 1/1b Study of ORIC-944 as a Single Agent or in Combination with an Androgen Receptor Pathway Inhibitor in Patients with Metastatic Prostate Cancer (ORIC-944-01) MOA: ORIC-944 is a highly selective, allosteric, small molecule inhibitor of PRC2 via binding the EED subunit. Documented progressive metastatic prostate cancer Must have undergone bilateral orchiectomy or be…

Sean Cronin, MD, received his medical degree from Michigan State University before completing a residency in gynecology and obstetrics at Einstein Medical Center in Philadelphia, PA. During his residency, he served as administrative chief resident. He then went on to complete a fellowship in gynecologic oncology at the National Capital Consortium in Bethesda, MD. While…

Samir Kanani, MD, is a board-certified radiation oncologist with Maryland Oncology Hematology. He received his medical degree from the University of Texas Medical Branch before completing a transitional year internship at Penn State Lehigh Valley. He then completed a residency in radiation oncology at the University of Maryland, where he also served as chief resident.…

Susan Prestera is a board-certified Acute Care Nurse Practitioner with over 15 years of clinical experience. Since earning her Master of Science in Nursing from Rutgers University in 2009, she has practiced in diverse specialties including gastroenterology, acute care surgery, surgical oncology, metabolic medicine, intensive care medicine, and urology. A member of the American Nurses Credentialing Center…