Coronavirus | Maryland Oncology Hematology Coronavirus – Maryland Oncology Hematology

Covid-19 Update

As we move into the heart of the holiday season, I know many of you are seeing the dramatic increase of COVID cases across Maryland and the U.S.  Throughout the pandemic, we’ve adjusted our policies to ensure the continued safety of our patients and staff, and we are now implementing some changes to promote the health and safety of our patients, staff, and community.

Effective Monday, December 27, all MOH practices will:

  • Implement a NO VISITOR policy.  Caregivers will only be provided access if the following criteria are met by the patient:
    • Wheelchair-bound requiring assistance.
    • Cognitive dysfunction.
    • Translator needed.
  • Leverage telemedicine visits as much as possible.

Thank you for your continued commitment as we work to keep each other, our patients, and our communities safe.  Warmest wishes for a healthy and happy holiday season.


Do I need to get a COVID-19 vaccine booster?

As of Friday August 13th, the CDC is now recommending that people with moderate to severe compromised immune systems should receive an additional dose (booster) of the COVID-19 vaccine after the initial two-dose vaccine series. At MOH, many of our patients have moderately to severely compromised immune systems and do not always build the same level of immunity compared to people with normal immune systems.  The CDC recommendation identifies people with a range of conditions including:

  • Those receiving active cancer treatment for tumors or cancers of the blood
  • Those that have had a bone marrow or stem cell transplant within the last 2 years or are taking medicine to suppress the immune system
  • Those with advanced or untreated HIV infection
  • Those actively being treated with high-dose corticosteroids or other drugs that may suppress your immune response


A full list of conditions can be found on CDC’s website.


Frequently Asked Questions (FAQs)


  1. Can you mix and match the vaccine type?

For people who received either Pfizer or Moderna’s COVID-19 vaccine series, a 3rd dose of the SAME mRNA vaccine should be used at least 4 weeks after completing the two-dose vaccine series.   A person should not receive more than three mRNA vaccine doses.


  1. What should immunocompromised people who received the J&J vaccine do?

The FDA’s & CDC’s recent amendment only applies to mRNA COVID-19 vaccines from Pfizer and Moderna.  There is not enough data at this time to determine whether immunocompromised people who received the J&J vaccine also have an improved antibody response following an additional dose of the same vaccine.


  1. Do I need a letter from my doctor in order to get the vaccine? 

At this time you do not need a letter from your physician in order to get the COVID-19 booster.  You will be able to self-attest that you meet criteria.


  1. If I am immunocompromised and I get the booster, can I stop wearing a mask?

While the Delta variant is surging, an additional vaccine dose for some people with weakened immune systems could help prevent serious and possibly life-threatening COVID-19 cases within this population.  Even after vaccination, people who are immunocompromised should continue follow current prevention measures (including wearing a mask, staying 6 feet apart from others they do not live with, and avoiding crowds and poorly ventilated indoor spaces) to protect themselves and those around them against COVID-19 until advised by your provider .


COVID-19 Vaccine and Cancer: What you need to know

The Coronavirus: Did we need a vaccine?

Every aspect of the Coronavirus disease 19 (COVID-19) pandemic has occurred at record speeds, from disease transmission to vaccine development. COVID-19, caused by a novel coronavirus known as SARS-CoV-2, targets the respiratory system. Most people experience flu-like symptoms; however, in the elderly and those with comorbidities, mild respiratory issues can quickly progress to Acute Respiratory Distress Syndrome, resulting in multiple organ failure and death.

The highly contagious nature of this virus, which is spread through droplets and aerosols released when an infected person sneezes or coughs, is evident by the fact that over 106 million COVID-19 cases have been reported worldwide. Over 2.35 million people have already succumb to the virus1–3.

The limitations of hospital capacity, ventilators, and healthcare personnel have been constant concerns throughout this pandemic. Worldwide regulations promoting social distancing and hygiene have prevented transmission, but they have also crippled the economy and stifled social freedoms1,2.

The overwhelming nature of this pandemic has led to the development of COVID-19 vaccines within an unprecedented timeframe. Despite the relief that this brings to some, many are concerned about the effects of the vaccine. A poll conducted by The Associated Press-NORC Center for Public Affairs research reported that of the 20% of Americans that did not want the COVID-19 vaccine, 70% were concerned about side effects4. Furthermore, the speed with which the COVID-19 vaccines were developed have left many questioning whether proper precautions and protocols are still being implemented. The Food and Drug Association (FDA) has stated that vaccine production will be in accordance with legal and regulatory guidelines5.

A cancer patient, who’s immune system is likely compromised by the effects of chemotherapy, would be understandably concerned about the virus and possible risks associated with the vaccine. This article aims to provide insight into the COVID-19 vaccine, concerns for cancer patients, and recommendations of healthcare professionals.

The COVID-19 vaccine: development, efficacy, and side effects

A vaccine is considered effective when it reduces the infection rate,  disease severity, or disease transmission. One of the main goals of a vaccination strategy is to create herd immunity, which is a large population of people that are immune to a specific disease6. With the aid of new vaccine development technologies, human clinical trials for the first potential COVID-19 vaccine began on March 16th 2020, just 4 months following the outbreak7. On February 10th 2021, the New York Times Coronavirus Vaccine Tracker reported that 69 COVID-19 vaccines were in the human clinical trial phase8.

Vaccine development was previously a 10-15 year process, and had the COVID-19 vaccines been made in this manner, scientists would still be the exploratory phase of the development process9. Soon after the COVID-19 outbreak in China, scientists unraveled the genetic code for SARS-CoV-2, which serves as the blueprint for the virus’s structure10.Then, by studying the virus’s structure, a protein called the spike protein was found on the outer surface of SARS-CoV-2. Researchers found that SARS-CoV-2 uses the spike protein to bind to and enter human cells, where it can replicate and cause sickness11. The spike protein is now the main target for COVID-19 vaccines12.

Traditionally, vaccines contained a weak or inactivated form of a virus that would allow the body to train against a weakened opponent so it would be better prepared to fight the same virus during an actual infection13. The COVID-19 vaccine was developed using RNA technology, an idea that was introduced in the 90’s by French researchers14. An RNA vaccine contains an mRNA sequence, which is simply a refined version of the blueprint used to build a particular protein. Once in the body, cells can process this code to produce the protein. If this is a viral protein, the body recognizes it as foreign, and the immune system is trained to eliminate it. Some COVID-19 vaccines introduce the code for the spike protein so that the body will be trained to fight it when presented with the actual virus13. Two of the leading COVID-19 vaccines, BNT162b2 Pfizer-BioNTech and mRNA-1273 Moderna, which have been approved for emergency use in the U.S. and E.U., are mRNA vaccines that target this spike protein8,15. COVID-19 vaccines may require periodic updates, similar to the Influenza vaccine, in order to accommodate mutations16.

The Centers for disease control and prevention (CDC) reports a 94.1% efficacy with the Moderna vaccine based on 1 large Phase III clinical trial with 30,000 participants aged 18-95 that had not previously tested positive for COVID-19. Systemic adverse effects, described as mild to moderate, were more common after the 2nd dose. These effects were more severe in patients under 6517. Pain, swelling, and redness were reported as localized reactogenicity symptoms, while chills, fatigue, and headaches were listed as systemic adverse effects18. The World Health Organization (WHO) reported that the Moderna vaccine is safe in patients with comorbidities, such as hypertension or diabetes, and chronic infections, provided that their condition is stable and controlled. Due to the possibility of severe allergic reactions, vaccinees must be monitored for 15 minutes after administration. They also report that the effect on immunocompromised people has not been properly investigated. Persons who have previously tested positive for COVID-19 are not deterred from getting vaccinated, but are advised to wait 6 months19.


Both the Moderna and Pfizer vaccine require 2 doses for maximal efficacy. The New England Journal of Medicine reported 95% efficacy in persons that received both doses of the Pfizer vaccine and 52% efficacy is expected after the 1st dose20. A recent report from Israel described a 33% reduction in COVID-19 cases after the first dose. It is important to consider that the Israeli report is based on persons over 60 years, whereas the original Pfizer study included young people as well21. The Pfizer Emmergency Use Authorization Fact Sheet reports similar side effects to that of Moderna, and immunocompromised patients are asked to report their conditions beforehand22.

Female doctor showing two coronavirus vaccine options


The COVID-19 vaccine: considerations for cancer patients

Due to the heterogeneity in cancer patients, there has been some debate as to whether they should be considered a high-risk group. Morbidity and mortality rates between 5 and 61% have been reported in cancer patients that contract COVID-1923. The immunosuppressive effect of many cancer treatments make cancer patients more susceptible to infection. One literature review reported that 10/11 studies in COVID-19 patients reported higher fatalities in patients that also had cancer, especially hematological cancers. Such data argues that cancer patients should be also receive priority vaccination23,24.


Data concerning the effect of the COVID-19 vaccine in cancer patients is very scarce. Of the nearly 44,000 participants in the Pfizer clinical trial only 3.7% were cancer patients23. The immunosuppression in cancer patients caused by chemotherapy, radiation, and/or targeted therapy is also expected to reduce the efficacy of the vaccine. The goal of a vaccination is to elicit an immune response that will train the immune system to fight against a particular disease. A weakened immune system is less likely to respond to this challenge and may therefore be incapable of being trained25. Some have tried to compare the COVID-19 vaccine to the Influenza vaccine; however, studies reporting the vaccine efficacy in cancer patients who received the flu vaccine show that the outcome depends on the cancer type and treatment26–28.

Dr. Nora Disis, a medical oncologist and the director of the Institute of Translational Health and the Cancer Vaccine Institute at the University of Washington, suggests that vaccine dosage and the timing are points of concern, especially in patients in active treatment. She also suggested that cancer patients avoid vaccinations containing an active form of the virus as this could lead to infection in immunocompromised patients29.



Recommendations and reminders for cancer patients

Currently, no COVID-19 vaccines containing live virus have been approved for administration, therefore there should be no risk of becoming infected by the vaccine itself29. As studies of the vaccine in cancer patients are lacking, it is uncertain if cancer patients are susceptible to side effects other than those reported in the general population. The overall recommendation for cancer patients is to receive the vaccine as the risk of contracting the virus is far greater than the possibility of the vaccine being less effective30. We recommend that patients actively on treatment discuss with their oncologist the timing of vaccine administration.


Dr. Jeffrey Farma, a surgical oncologist at the Fox Chase Cancer Center in Pennsylvania, recommends that cancer patients with upcoming surgeries schedule enough time between surgery and the vaccination. Furthermore, patients that have undergone a bone marrow transplant should consult with their hematologist to determine when their immune system will be able to respond to the vaccine. All cancer patients or survivors should consult with their physicians before getting vaccinated31.


Time will tell if current COVID-19 vaccines provide long-term protection and whether they are effective against new variants. Therefore, the advice given to all vaccination recipients is to continue adhering to social distancing and hygiene regulations. Cancer patients, especially, should continue to protect themselves from unnecessary exposure to COVID-19 and any other diseases32,33.



Dr Juneja joins Maryland Oncology Hematology’s White Oak Cancer Center after 13 years of practice in Northern Virginia and Bethesda.  He has subspecialized in breast, gastrointestinal, lymphoma, and myeloma in his prior practices. He is very interested in clinical research and cutting edge as well as precision medicine. Previously, he has designed clinical trials with Bristol Myers Squibb, been a medical officer at the FDA, and has been an investigator in several clinical trials.

Having survived cancer himself, he completely understands what it is like to be a patient. He lives with his wife, 2 children, dog, and enjoys playing piano, tennis, running, bicycling, and sailing.




  1. Yuki, K., Fujiogi, M. & Koutsogiannaki, S. COVID-19 pathophysiology: A review. Clinical Immunology vol. 215 108427 (2020).
  2. Singhal, T. A Review of Coronavirus Disease-2019 (COVID-19). Indian Journal of Pediatrics vol. 87 281–286 (2020).
  3. COVID-19 situation update worldwide, as of week 5, updated 11 February 2021.
  4. Expectations for a COVID-19 Vaccine – AP-NORC.
  5. Shah, A., Marks, P. W. & Hahn, S. M. Unwavering Regulatory Safeguards for COVID-19 Vaccines. JAMA – Journal of the American Medical Association vol. 324 931–932 (2020).
  6. Hodgson, S. H. et al. What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2. The Lancet Infectious Diseases vol. 21 e26–e35 (2021).
  7. Le, T. The COVID-19 vaccine development landscape. doi:10.1038/d41573-020-00073-5.
  8. Zimmer, C., Corum, J. & Wee, S.-L. Covid-19 Vaccine Tracker Updates: The Latest – The New York Times.
  9. Government Accountability Office, U. GAO-20-583SP, Science & Tech Spotlight: COVID-19 Vaccine Development.
  10. Zhou, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579, 270–273 (2020).
  11. Ou, X. et al. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat. Commun. 11, 1–12 (2020).
  12. Mahase, E. How the Oxford-AstraZeneca covid-19 vaccine was made. The BMJ vol. 372 (2021).
  13. RNA vaccines: an introduction | PHG Foundation.
  14. Dolgin, E. How COVID unlocked the power of RNA vaccines. Nature 589, 189–191 (2021).
  15. Dai, L. & Gao, G. F. Viral targets for vaccines against COVID-19. Nature Reviews Immunology vol. 21 73–82 (2020).
  16. Callaway, E. & Ledford, H. How to redesign COVID vaccines so they protect against variants. Nature 590, 15–16 (2021).
  17. Oliver, S. E. et al. The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine — United States, December 2020. MMWR. Morb. Mortal. Wkly. Rep. 69, 1922–1924 (2020).
  18. Information about the Moderna COVID-19 Vaccine | CDC.
  19. The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know.
  20. Polack, F. P. et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N. Engl. J. Med. 383, 2603–2615 (2020).
  21. Mahase, E. Covid-19: Reports from Israel suggest one dose of Pfizer vaccine could be less effective than expected. BMJ 372, n217 (2021).
  22. Inc, P. Pfizer COVID-19 Vaccine EUA Fact Sheet for Recipients and Caregivers.
  23. Ribas, A. et al. Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply Is Limited. Cancer Discov. 11, 233–236 (2021).
  24. ASH-ASTCT COVID-19 and Vaccines: Frequently Asked Questions –
  25. Yap, T. A. et al. SARS-CoV-2 vaccination and phase 1 cancer clinical trials. Lancet Oncol. 0, (2021).
  26. Ayoola, A. et al. Efficacy of influenza vaccine (Fluvax) in cancer patients on treatment: a prospective single arm, open-label study. Support. Care Cancer 28, 5411–5417 (2020).
  27. Zhang, L. et al. Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China. Ann. Oncol. 31, 894–901 (2020).
  28. Yri, O. E. et al. Rituximab blocks protective serologic response to influenza A (H1N1) 2009 vaccination in lymphoma patients during or within 6 months after treatment. Blood 118, 6769–6771 (2011).
  29. COVID-19 Vaccines and Cancer Patients: 4 Things to Know.
  30. COVID-19 Vaccines and Cancer.
  31. COVID-19 Vaccines: Here is What Cancer Patients and Survivors Need to Know Now | Fox Chase Cancer Center – Philadelphia, PA.
  32. What cancer patients need to know about COVID-19 vaccines | CTCA.
  33. Oncologists can allay COVID-19 vaccination concerns of patients with cancer, survivors.

COVID-19 Vaccines for Patients Frequently Asked Questions* (FAQ)

 Q – Which vaccines are available?

  • At this time, two vaccines have been submitted for United States Food and Drug (FDA) Emergency Use Authorization (EUA).
  • Vaccine availability in Maryland will depend on a number of factors including availability as well as vaccine storage capabilities.
  • General information published about each vaccine includes:
    • The Pfizer-BioNTech vaccine: Contains a tiny fragment of the virus’s genetic code made in the lab – called messenger RNA, or mRNA – that codes for a part of the virus called the ‘spike protein’, which sits on the outside of the virus. When the mRNA is injected into the body it can instruct cells to produce these proteins, priming the immune system to be able to recognize and destroy the coronavirus, without exposing the body to the virus itself. This vaccine must be stored at -70°C (-94 oF). This vaccine received FDA EUA approval on December 11, 2020.
  • Moderna vaccine: Like the Pfizer-BioNTech vaccine, the Moderna vaccine contains mRNA that codes for the virus’s spike protein. It can be stored at –20°C

(-4oF; normal freezer temperature) for up to 6 months. This vaccine received FDA EUA approval on December 17, 2020.


Q – Which vaccine is most appropriate for me?

  • All the vaccines that are approved by the FDA may be considered.


Q – Is the vaccine effective against COVID-19?

  • Detailed information about the effectiveness of each vaccine is available from the respective manufacturers, the FDA and the CDC. Based on clinical trials reviewed by the FDA:
  • The Pfizer vaccine is 95% effective 7 days from the 2nd dose.
  • The Moderna vaccine is 94.5% effective 14 days from the 2nd dose
  • Ongoing studies to assess how well the vaccine works in real-world conditions will continue.


Q – How do we know the vaccine is safe?

  • FDA EUA approval requires the same rigorous review of clinical trial data as any other FDA approval.


Q – Is the vaccine safe if I am receiving immunotherapy?

  • Based on information studying the influenza vaccines, it appears that vaccines are safe to use in this population of patients. Further information on the COVID-19 vaccines, is not available currently.
  • We will continue to monitor for information and guidance on immunization in special populations including patients on immunotherapy.

Q – Has it been studied/is it safe in immunocompromised individuals? What about in pregnancy and children?

  • The EUA for the Pfizer-BioNTech vaccine is for ages 16 and older.
  • There is no published data in the studies on this; however, we will continue to monitor for published guidance.
  • There have been no published studies to include pregnant women or children <12 yrs. of age. These data points are still being collected.


Q – What are the common side effects?

  • Each vaccine manufacturer has identified various possible side effects for its respective vaccine. Information about side effects is available from each manufacturer, but some reported side effects include:
  • Pfizer-BioNTech vaccine
    • Fatigue 3.8%
    • Headache 2.0%
    • Older adults demonstrated fewer side effects
  • Moderna vaccine
    • Injection site pain 2.7%
    • Fatigue 9.7%
    • Myalgia (muscle aches and pains) 8.9%
    • Arthralgia (joint pain) 5.2%
    • Headache 4.5%
    • Pain 4.1%
    • Erythema (superficial redness of the skin) 2.0%


Q – Will vaccination help or hinder my response to treatment?

  • There is no published data in the studies on this; however, the decision to receive the vaccine should be made after consultation with your health care provider.


Q – What happens if I refuse to receive the vaccine?

  • You as a patient always have the right to refuse any treatment. Your provider should provide adequate education to ensure you can make an informed decision.


Q – How soon after I get the vaccine will I become protected from contracting COVID-19?

  • According to the manufacturer, the Pfizer vaccine provides optimal immunity 7 days after the second dose.
  • According to the manufacturer, the Moderna provides optimal immunity 14 days after the second dose.
  • Other COVID-19 precautions such as mask wearing, hand washing, and social distancing should be continued after vaccination. It has not been clearly established at what point after vaccination it is safe to discontinue other COVID-19 precautions.


Q – Can I get COVID-19 from getting the vaccine?

  • Per the CDC you cannot develop COVID-19 from vaccines that do not use the live virus.
  • There are several different types of vaccines in development. The goal for each of them is to teach our immune systems how to recognize and fight the virus that causes COVID-19. Sometimes this process can cause symptoms, such as fever. These symptoms are normal and are a sign that the body is building immunity.




*These FAQs consolidate into one document information published or otherwise provided by the Centers for Disease Control, the World Health Organization, the US Food and Drug Administration, professional societies, academic centers, and other experts. Any recommended courses of action made by the foregoing agencies or experts and included in this document are only recommendations.








Covid19 Vaccine Update

December 22, 2020

To Our Valued MOH Patients:

Many of you have seen in the news that the COVID-19 vaccine approvals were recently
announced by the FDA. The arrival of vaccines is good news in the fight to defeat COVID-19,
but now the challenge begins in the distribution and administration of the vaccine. Although
the Maryland Department of Health has a draft mass vaccination plan (click here), MOH has not
been provided information regarding COVID-19 vaccine availability for our practice and

As frontline caregivers, our goal is to protect the health and well being of our patients, staff and
communities. We will continue to monitor the situation closely and keep you updated and
informed as more information becomes available on the COVID-19 vaccine via our website.
Please remember that until the population has been broadly immunized, we encourage you to
continue to protect yourself and others by wearing a mask, maintaining social distancing and
washing your hands.

Know that your health and safety continues to be our top priority and we will get through this

Thank you and Happy Holidays.

Joseph Haggerty MD



Jenny Elrod MSN, RN

Director Clinical Services
Maryland Oncology Hematology


Protecting our patients against Coronavirus

Maryland Oncology Hematology Remains committed to the safety of our patients, visitors, and staff during the Coronovirus pandemic. Please take a few minutes to review our video that talks about all of the precations Maryland Oncology Hematology has put in place to safeguard from Covid-19. If you have any questions about the most recent rules and procedures put into place, call your local MOH office. We remain committed to providing the most advanced cancer treatment throughout the Maryland region. As times change, so do your options in advanced cancer treatment. Because hope carried on.


There are more than 200 testing sites available throughout Maryland. Location, contact, and scheduling information for many of the COVID-19 testing sites in Maryland can be found at…. If you plan to travel, we encourage you to review the Centers for Disease Control and Prevention website on considerations for travelers—Coronavirus in the US


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